CVE-2026-31964

HTSlib CRAM decoder has a NULL Pointer Dereference

HIGH
7.5
CVSS Score
Published: March 18, 2026 at 06:27 PM UTC
Updated: June 17, 2026 at 10:34 AM UTC
2 products affected across 2 vendorsHtslibHTSlib

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Severity
HIGH7.5
Exploit prediction
EPSS 0.3%
SSVC
No known exploit

Description

HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data using a variety of encodings and compression methods. While most alignment records store DNA sequence and quality values, the format also allows them to omit this data in certain cases to save space. Due to some quirks of the CRAM format, it is necessary to handle these records carefully as they will actually store data that needs to be consumed and then discarded. Unfortunately the `CONST`, `XPACK` and `XRLE` encodings did not properly implement the interface needed to do this. Trying to decode records with omitted sequence or quality data using these encodings would result in an attempt to write to a NULL pointer. Exploiting this bug causes a NULL pointer dereference. Typically this will cause the program to crash. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.

Affected

Our own answer: ranges merged, affected separated from platform-only, with confidence and review flags.

v < 1.21.11.22 ≤ v < 1.22.21.23
v < 1.21.1v < 1.22.2= 1.23
Affected range stops below 1.21.1, so it looks safe — our inference, not a vendor statement
Affected range stops below 1.22.2, so it looks safe — our inference, not a vendor statement

Remediation

No guide yet

No remediation guidance has been written for this CVE yet. What the record does show:

References (2)

SSVC — Action Prioritization

SSVCNo known exploitAutomatablePartial impact

SSVC signals action urgency (what to patch first), separate from CVSS which measures severity.

CVSS

Attack Vector
NETWORK
Complexity
LOW
Privileges
NONE
User Interaction
NONE
Scope
UNCHANGED
Confidentiality
NONE
Integrity
NONE
Availability
HIGH
Vector?

Quick Info

StatusANALYZED
CWE
CWE-476

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